Somebody posted a pic of one on here one time. Seemed to work pretty well being as the boat was also used for drag racing. A 300 should only be around a hundred pounds heavier; a little less setback should take care of that. The 02 hull should easily handle it, especially if its a Tournament model as they are no light weight by any stretch of the imagination. Theres been several OMC big block rigs ran over the years. Also a guy told us about his GS-300 combo a while back. Ran 110 according to him, no handling issues. Also BadBait over on the left coast rigged his 2003 with a 3 litre 250 and made it work great. A pm to him would be worth the effort.
For a novice A-boat owner I would have my doubts, but for a seasoned veteran I would say go for it. Running a hundred turning an effortless 6500 sounds like a nice lake boat.
A couple less inches of setback and keep the propshaft at a conservative position, say maybe an eigth below should be a good starting point. Keep us posted.